Riluzole therapy in cervical dystonia
Identifieur interne : 004302 ( Main/Exploration ); précédent : 004301; suivant : 004303Riluzole therapy in cervical dystonia
Auteurs : Jörg Müller [Autriche] ; Gregor K. Wenning [Autriche] ; Jörg Wissel [Autriche] ; Angelika Baldauf [Autriche] ; Klaus Seppi [Autriche] ; Christian Brenneis [Autriche] ; Werner Poewe [Autriche]Source :
- Movement Disorders [ 0885-3185 ] ; 2002-01.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Adulte.
English descriptors
- KwdEn :
- Adult, Anticonvulsants (therapeutic use), Benzothiazole, Case study, Cervical Vertebrae (physiopathology), Chemotherapy, Dystonia, Dystonia (drug therapy), Dystonia (physiopathology), Female, Humans, Male, Middle Aged, Muscle relaxant, Neck, Pilot Projects, Prognosis, Psychotropic, Refractory, Riluzole, Riluzole (therapeutic use), Treatment.
- MESH :
- chemical , therapeutic use : Anticonvulsants, Riluzole.
- drug therapy : Dystonia.
- physiopathology : Cervical Vertebrae, Dystonia.
- Adult, Female, Humans, Male, Middle Aged, Pilot Projects.
Abstract
We conducted a 6‐week open‐label pilot study with blinded video rating of riluzole (50 mg twice a day) in six patients with cervical dystonia (CD) refractory to botulinum toxin A and oral pharmacological treatment. The Tsui rating scale served as primary efficacy measure and improved significantly under riluzole (P = 0.002). In three of six patients, the Tsui score improved by more than 30% with a greater 50% reduction in the head tremor/jerk subscore of the Tsui scale. These data suggest that riluzole may be helpful in a subgroup of patients with disabling CD refractory to other therapies. © 2001 Movement Disorder Society.
Url:
DOI: 10.1002/mds.1200
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">We conducted a 6‐week open‐label pilot study with blinded video rating of riluzole (50 mg twice a day) in six patients with cervical dystonia (CD) refractory to botulinum toxin A and oral pharmacological treatment. The Tsui rating scale served as primary efficacy measure and improved significantly under riluzole (P = 0.002). In three of six patients, the Tsui score improved by more than 30% with a greater 50% reduction in the head tremor/jerk subscore of the Tsui scale. These data suggest that riluzole may be helpful in a subgroup of patients with disabling CD refractory to other therapies. © 2001 Movement Disorder Society.</div>
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